Inducement of experimental Abdominal Adhesions (literature review)
https://doi.org/10.29413/ABS.2018-3.6.15
Abstract
Adhesive disease of the abdominal cavity is a common medical problem that impairs the patients’ life quality. Adhesive intestinal obstruction ranks first in the structure of acute bowel obstruction. The levels of complications and postoperative mortality are not likely to decrease. Consequently, the studies on preventing adhesive disease are still in progress, which requires an animal model to induce abdominal adhesive process. Numerous factors of peritoneum injury result in adhesion formation. Experimental surgery offers various techniques of inducing the adhesive process in the abdominal cavity based on mechanical, chemical, biological, implantation injury factors. Recent trends in intra-abdominal adhesion stimulation are designed to approximate at maximum an animal model and present surgical and gynecologic procedures. In the review article, we survey and systematize different ways of inducing intra-abdominal adhesive process with various injury factors. The choice of study animal, the ways of peritoneum injury, followed by septic or aseptic inflammation are analyzed. The rating scales for the severity of adhesive process are also organized and compared. The number of existing models is large which is evident of the outstanding problem and promising outlook of scientific research.
About the Authors
N. I. Ayushinova
Irkutsk Scientific Centre of Surgery and Traumatology;
Irkutsk State Medical University
Russian Federation
Russian Federation
Natalya I. Ayushinova – Cand. Sc. (Med.), Surgeon at the Unit of Purulent Surgery N 1, Irkutsk Scientific Centre of Surgery and Traumatology; Associate Professor at the Department of Advanced Level Surgery, Irkutsk State Medical University
664049, Irkutsk, Yubileyniy, 100
I. A. Shurygina
Irkutsk Scientific Centre of Surgery and Traumatology
Russian Federation
Russian Federation
Irina A. Shurygina – Dr. Sc. (Med.), Professor of RAS, Deputy Director for Science
664003, Irkutsk, ul. Bortsov Revolyutsii, 1
E. G. Grigoriev
Irkutsk Scientific Centre of Surgery and Traumatology;
Irkutsk State Medical University
Russian Federation
Russian Federation
Evgeniy G. Grigoriev – Dr. Sc. (Med.), Professor, Corresponding Member of RAS, Scientific Advisor, Irkutsk Scientific Centre of Surgery and Traumatology; Head of the Department of Advanced Level Surgery, Irkutsk State Medical University
664049, Irkutsk, Yubileyniy, 100
M. G. Shurygin
Irkutsk Scientific Centre of Surgery and Traumatology
Russian Federation
Russian Federation
Mikhail G. Shurygin – Dr. Sc. (Med.), Head of the Scientific Laboratory Department
664003, Irkutsk, ul. Bortsov Revolyutsii, 1
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Review
For citations:
Ayushinova N.I., Shurygina I.A., Grigoriev E.G., Shurygin M.G. Inducement of experimental Abdominal Adhesions (literature review). Acta Biomedica Scientifica. 2018;3(6):107-113. (In Russ.) https://doi.org/10.29413/ABS.2018-3.6.15
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